Pharmacological Investigation of Ritodrine Hydrochloride, a Beta2-Adrenoceptor Stimulant

pharmacological interventions in stimulant dependence

advances in understanding the neurobiology of addiction to stimulants, has made it possible for researchers to identify medicines effective in initiation of treatment and prevention of stimulants relapse, based on pharmacological effects of various medicine. some of these medicine and vaccines have brought promising results in clinical trials on cocaine dependent patients. studies regarding met...

Indacaterol: a new once daily long-acting beta2 adrenoceptor agonist

INTRODUCTION Indacaterol is a novel once daily long-acting beta agonist (LABA) developed for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. AIMS This review summarizes preclinical and clinical data of indacaterol, including all data generated during the phase II trial program, and further discusses the outlook and potential of the drug in the future treatment of COP...

Effectiveness and safety of ritodrine hydrochloride for the treatment of preterm labour: a systematic review.

PURPOSE To analyse the available data on the effectiveness and safety of ritodrine hydrochloride in delaying delivery and in decreasing the incidence of preterm birth. METHODS Systematic review of randomised controlled trials (RCTs) that compared the effectiveness and safety of ritodrine hydrochloride with a placebo or with no treatment. Main outcome measures were relative risks (RRs) for per...

Pharmacological properties of beta-adrenoceptor blocking drugs

Simultaneous alpha2B- and beta2-adrenoceptor activation sensitizes the alpha2B-adrenoceptor for agonist-induced down-regulation.

We recently reported that alpha(2A)-adrenoceptor (AR) desensitization and down-regulation occurs after 24-h treatment with epinephrine (EPI) (0.3 microM) in BE(2)-C cells that express both alpha(2)- and beta(2)-ARs. The same concentration of norepinephrine (NE) has no effect. The effect of EPI is prevented by beta(2)-AR blockade and is associated with an increase in G protein-coupled receptor k...